Lei Yuan Selected Research

ASPER-29

1/2023	Design and synthesis of dual cathepsin L and S inhibitors and antimetastatic activity evaluation in pancreatic cancer cells.
2/2022	ASPER-29 suppresses the metastasis of pancreatic cancer cells by dual inhibition of cathepsin-L and cathepsin-S.

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Lei Yuan Research Topics

Disease

49	Neoplasms (Cancer) 01/2024 - 06/2012
14	Breast Neoplasms (Breast Cancer) 01/2023 - 06/2012
11	Infections 03/2024 - 01/2016
9	Ovarian Neoplasms (Ovarian Cancer) 11/2023 - 04/2015
9	Neoplasm Metastasis (Metastasis) 02/2022 - 12/2018
8	Inflammation (Inflammations) 01/2023 - 05/2009
7	Carcinoma (Carcinomatosis) 07/2022 - 06/2012
6	Hypoxia (Hypoxemia) 08/2022 - 05/2009
5	Hepatocellular Carcinoma (Hepatoma) 01/2024 - 01/2018
5	Pancreatic Neoplasms (Pancreatic Cancer) 01/2023 - 01/2015
5	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/2023 - 01/2016
5	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 02/2021 - 04/2016
4	Glioma (Gliomas) 04/2024 - 12/2019
4	Lymphatic Metastasis 02/2024 - 01/2016
4	Prostatic Neoplasms (Prostate Cancer) 02/2024 - 01/2019
4	Scoliosis 12/2023 - 08/2021
4	Body Weight (Weight, Body) 09/2023 - 05/2015
4	Endometriosis 05/2022 - 11/2008
4	Pain (Aches) 11/2021 - 07/2013
3	Ovarian Epithelial Carcinoma 04/2024 - 01/2020
3	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 04/2024 - 01/2014
3	Obesity 03/2024 - 07/2014
3	Non-alcoholic Fatty Liver Disease 12/2023 - 03/2014
3	Virus Diseases (Viral Diseases) 11/2023 - 12/2016
3	COVID-19 11/2022 - 11/2021
3	Dysmenorrhea (Menstrual Pain) 05/2022 - 01/2008
3	Necrosis 07/2020 - 04/2016
3	Lymphoma (Lymphomas) 06/2019 - 07/2011
3	Leukemia 01/2019 - 06/2016
3	Neuralgia (Stump Neuralgia) 01/2019 - 01/2014
3	Graft vs Host Disease (Graft-Versus-Host Disease) 10/2018 - 07/2011
2	Ascites 02/2024 - 05/2022
2	Ischemic Stroke 12/2023 - 11/2013
2	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 09/2023 - 10/2019
2	Insulin Resistance 09/2023 - 10/2019
2	Colonic Neoplasms (Colon Cancer) 06/2023 - 01/2018
2	Alzheimer Disease (Alzheimer's Disease) 06/2023 - 11/2014
2	Cognitive Dysfunction 01/2023 - 05/2009
2	Immune System Diseases (Immune Disorders) 05/2022 - 07/2020
2	B-Cell Lymphoma (Lymphoma, B Cell) 02/2021 - 10/2014
2	Hematologic Neoplasms (Hematological Malignancy) 02/2021 - 02/2021
2	Pregnancy Complications 02/2020 - 05/2019

Drug/Important Bio-Agent (IBA)

17	Proteins (Proteins, Gene)FDA Link 11/2023 - 06/2012
13	Biomarkers (Surrogate Marker)IBA 03/2024 - 11/2008
6	Long Noncoding RNAIBA 04/2024 - 11/2018
6	CytokinesIBA 08/2022 - 05/2009
5	Glucose (Dextrose)FDA LinkGeneric 03/2024 - 01/2020
5	Chimeric Antigen ReceptorsIBA 12/2023 - 12/2015
5	RNA (Ribonucleic Acid)IBA 06/2023 - 05/2009
5	asperphenamateIBA 01/2023 - 08/2012
5	Small Interfering RNA (siRNA)IBA 01/2020 - 05/2009
4	PlatinumIBA 02/2024 - 05/2020
4	AntigensIBA 01/2023 - 06/2016
4	Cathepsin LIBA 01/2023 - 01/2020
4	NF-kappa B (NF-kB)IBA 08/2022 - 11/2008
4	CathepsinsIBA 02/2022 - 12/2018
3	Anti-Bacterial Agents (Antibiotics)IBA 12/2023 - 08/2013
3	LipidsIBA 12/2023 - 03/2022
3	Estrogens (Estrogen)FDA Link 01/2023 - 12/2012
3	Transcription Factors (Transcription Factor)IBA 02/2022 - 05/2009
3	Messenger RNA (mRNA)IBA 07/2020 - 12/2015
3	LigandsIBA 01/2019 - 12/2016
3	Cadherins (E-Cadherin)IBA 04/2017 - 10/2015
3	Sodium Channels (Sodium Channel)IBA 06/2015 - 04/2014
2	LuciferasesIBA 04/2024 - 01/2018
2	Linezolid (Zyvox)FDA Link 01/2024 - 01/2018
2	AntioxidantsIBA 12/2023 - 07/2014
2	EnzymesIBA 12/2023 - 12/2023
2	Prostate-Specific Antigen (Semenogelase)IBA 09/2023 - 04/2020
2	vasectrin I (VS I)IBA 06/2023 - 01/2019
2	ASPER-29IBA 01/2023 - 02/2022
2	InflammasomesIBA 01/2023 - 01/2021
2	Estrogen ReceptorsIBA 01/2023 - 12/2012
2	Ligases (Synthetase)IBA 01/2023 - 05/2015
2	UbiquitinIBA 01/2023 - 05/2015
2	CollagenIBA 09/2022 - 01/2020
2	Immunologic Factors (Immunomodulators)IBA 05/2022 - 07/2020
2	Gonadotropin-Releasing Hormone (GnRH)FDA Link 05/2022 - 07/2013
2	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 02/2022 - 03/2018
2	4-boronic acid benzophenoneIBA 02/2022 - 08/2012
2	cathepsin SIBA 02/2022 - 12/2018
2	Immune Checkpoint InhibitorsIBA 01/2022 - 12/2021
2	Programmed Cell Death 1 ReceptorIBA 01/2022 - 03/2018
2	Cisplatin (Platino)FDA LinkGeneric 01/2022 - 01/2020
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/2020 - 12/2016
2	Particulate MatterIBA 02/2020 - 05/2019

Therapy/Procedure

31	Therapeutics 04/2024 - 08/2013
12	Drug Therapy (Chemotherapy) 03/2024 - 09/2015
11	Hematopoietic Stem Cell Transplantation 01/2019 - 07/2011
9	Immunotherapy 02/2024 - 12/2015
4	Spinal Fusion (Spondylosyndesis) 05/2023 - 08/2021
4	Hysterectomy 01/2023 - 09/2014
3	Cytoreduction Surgical Procedures 11/2023 - 05/2020
3	Artificial Respiration (Mechanical Ventilation) 11/2022 - 11/2021
3	Chinese Traditional Medicine (Traditional Chinese Medicine) 06/2021 - 05/2017
2	Stem Cell Transplantation 04/2024 - 01/2014
2	Gastrectomy 03/2024 - 07/2023
2	Reoperation 12/2023 - 10/2019
2	Radiotherapy 01/2023 - 01/2020
2	Mechanical Ventilators (Ventilator) 01/2022 - 11/2021